Leucine-rich repeat-containing protein 49 (LRRC49)

Leucine-rich repeat-containing protein 49 (LRRC49) is a protein encoded by the LRRC49 gene in humans and is primarily localized in centriolar satellites within the cytoplasm[1][7]. It serves as a subunit of the tubulin polyglutamylase complex (TPGC), which plays an essential role in microtubule polyglutamylation—critical for cilia and flagella biogenesis and motility[2][7]. LRRC49 has context-dependent roles in cellular architecture and signaling: it regulates microtubule polymerization, cilium disassembly, and nuclear shape. In breast cancer, LRRC49 transcript levels are influenced by estrogen receptor status and epigenetic regulation; its down-regulation via promoter hypermethylation is common in tumors, suggesting a role in carcinogenesis[1]. LRRC49 is also highly expressed in podocytes, supporting functions in kidney filtration barrier maintenance, and is genetically linked to cardiovascular disease risk[1]. There are no known drug interactions or therapeutic targeting for LRRC49 at present. LRRC49 is not currently regarded as a classic therapeutic target such as a receptor or enzyme but is recognized as an important multifunctional regulatory protein in human cellular biology[1][2][7].

Other names

Leucine-rich repeat-containing protein 49LRRC49CSTPP2PGs4FLJ20156Centriolar satellite-associated tubulin polyglutamylase complex regulator 2Tubulin polyglutamylase complex subunit 4Leucine rich repeat containing 49Polyglutamylase subunit 4LRC49_HUMAND430025H09RikLOC100504571p79RGD1309466