Leucine-rich repeat-containing protein 51 (LRRC51)

Leucine-rich repeat-containing protein 51 (LRRC51) is a member of the leucine-rich repeat (LRR) containing protein family, believed to be involved in scaffolding or regulatory roles within cells due to the presence of LRR protein–protein interaction motifs[4][8]. The human LRRC51 protein contains a transmembrane domain and two leucine-rich repeat domains[4][8]. Historical annotations sometimes conflated LRRC51 with LRTOMT (a nearby gene involved in O-methyltransferase activity), but these are now split into three distinct genetic loci due to readthrough transcription in primates, clarifying that LRRC51 itself is not the same as LRTOMT[4][2]. In model organisms such as zebrafish and mice, LRRC51 orthologs do not have O-methyltransferase activity and are located in the nucleus[6][2]. Functional details and disease roles of LRRC51 remain limited, with some literature suggesting a potential role in deafness, but no evidence supporting its use as a typical therapeutic target (such as a receptor, enzyme, transporter, or channel)[4][8][2]. There is a high risk of confusion with LRTOMT, a confirmed enzyme important in auditory function and known for its involvement in certain forms of deafness; this is a distinct protein despite the historical overlap and "readthrough" transcripts in some annotations[4][2]. LRRC51 currently lacks substantial evidence as a direct drug target and should not be considered a canonical therapeutic target.

Other names

LRRC51leucine rich repeat containing 51LRTOMT (historically and in some contexts)Protein LRTOMT1lrrp51zgc:153736

Not applicable (no documented drug interactions)