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Leucine-rich repeat-containing protein 61 (LRRC61)
- Target
- LRRC61
- Molecular classification
- Protein-coding gene, Leucine-rich repeat domain superfamily (contains leucine-rich repeat motifs), “Other” (no evidence for receptor, enzyme, transporter, transcription factor, or related class)
01
Overview
Leucine-rich repeat-containing protein 61 (LRRC61) is a cytoplasmic protein encoded by the LRRC61 gene on human chromosome 7. It belongs to the leucine-rich repeat domain superfamily, characterized by regions containing the leucine-rich repeat motif. LRRC61 is predicted to bind alpha-tubulin and dynein heavy chain, suggesting a role in the assembly of the outer dynein arm, critical for the structure and function of cellular cilia and flagella. Its paralog is LRRC9. LRRC61 is not currently recognized as a therapeutic target, and there is no direct mechanistic link to human disease, though some database associations with hypophosphatasia exist. No drugs, biomarkers, or safety concerns are documented for this protein. In summary, LRRC61 is a structurally annotated cytoplasmic protein involved with the cytoskeleton, with limited functional characterization and no current clinical relevance as a drug target.
- Other names
- LRRC61HSPC295MGC3036FLJ31392leucine-rich repeat-containing protein 61
02
Mechanism of action
None reported. There is no documented mechanism of drug action for LRRC61
03
Biological functions
Alpha-tubulin bindingDynein heavy chain bindingInvolved in outer dynein arm assembly, likely contributing to ciliary or flagellar structure/functionPredicted cytoplasmic activity
04
Disease associations
No well-established disease roles.Gene is associated in database annotation with Hypophosphatasia, Infantile and Hypophosphatasia, but direct causality or mechanistic involvement is not established.“Other” (potential future relevance in ciliary/dynein-related diseases, but not currently supported)
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