Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Leucine-rich repeat-containing protein 71 (LRRC71)
- Target
- LRRC71
- Molecular classification
- Other (leucine-rich repeat-containing protein; not classically a receptor, enzyme, transporter, or transcription factor), Protein with leucine-rich repeats
01
Overview
Leucine-rich repeat-containing protein 71 is a poorly characterized protein encoded by the LRRC71 gene. The protein is defined by the presence of leucine-rich repeat motifs, which are commonly involved in mediating protein-protein interactions and are implicated in diverse cellular functions. Recent systematic CRISPR-Cas9 screening and machine learning analyses have identified LRRC71 as a component within functional networks altered in glioblastoma multiforme, which suggests a potential role in tumorigenesis and patient prognosis. However, its precise molecular function has not been elucidated, and there are currently no approved drugs or direct therapeutic interventions targeting LRRC71. The protein may serve as a candidate biomarker for cancer prognosis, but additional studies are required to clarify its mechanistic biology[1][7].
- Other names
- LRRC71C1orf92FLJ32884Leucine-rich repeat-containing protein 71
02
Mechanism of action
null
03
Biological functions
Likely involved in protein-protein interactions due to leucine-rich repeat domainsImplicated as a candidate biomarker for prognosis in glioblastoma multiforme via association with the Wnt/β-catenin signaling pathwayMay participate in cellular signaling networks; specifics remain uncharacterized
04
Disease associations
Cancer (specifically, glioblastoma multiforme network connectivity, associated with patient survival)Other (potential involvement in cancer biology through Wnt/β-catenin signaling, but limited direct evidence for other diseases)
05
Biomarkers
LRRC71 may act as a biomarker for survival prognosis in glioma/glioblastoma multiforme patients
Beyond the preview
Go deeper on Leucine-rich repeat-containing protein 71 (LRRC71).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Leucine-rich repeat-containing protein 71 (LRRC71).