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Target intelligence / Profile preview
Leucine-rich repeat-containing protein 9 (LRRC9)
- Target
- LRRC9
- Molecular classification
- Other (Leucine-rich repeat-only protein; does not fall into established drug target classes like receptor, enzyme, channel, or transporter), Pseudoenzyme (contains an atypical, likely catalytically inactive, ART [ADP-ribosyltransferase]-like domain)
01
Overview
Leucine-rich repeat-containing protein 9 (LRRC9) is a human protein encoded by the LRRC9 gene. It features multiple leucine-rich repeats (LRR), a structural motif often associated with protein-protein interactions and signal transduction. LRRC9 lacks domains typical of canonical receptor, enzyme, or channel targets, and appears to function primarily as a multifunctional signaling adaptor. Bioinformatics analyses suggest it contains an atypical ADP-ribosyltransferase-like domain but lacks the residues necessary for enzymatic activity, suggesting a “pseudoenzyme” function. It is predicted to be involved in mRNA splicing via the spliceosome, may bind U2 snRNA, and is localized to the cytoplasm. Population genomics implicates LRRC9 in developmental and reproductive regulation (notably in some fish species), and it may serve as a link between environmental/pathogen detection and cell signaling in processes such as immune defense and development. There are currently no established roles for LRRC9 in human pathology, no drugs targeting it, and no evidence it is used as a biomarker or presents notable safety/therapeutic challenges.
- Other names
- LRRC9FLJ46156Leucine-rich repeat-containing 9
02
Mechanism of action
Not applicable (no known drugs or inhibitors)
03
Biological functions
mRNA splicing (via spliceosome)U2 snRNA binding (predicted)Signaling adaptor, potentially integrating immune, developmental, and behavioral signaling pathwaysDevelopmental regulation and possibly modulation of reproductive behaviorImmune defense (suggested by patterns of sequence and expression)
04
Disease associations
Other: Implicated in reproductive trait evolution in fish (sockeye salmon), but not directly in major human diseasesNo strong evidence for involvement in specific human disease categories (such as cancer, inflammation, neurodegeneration, etc.) as of now
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