Leucine-rich repeat flightless-I-interacting protein 2 (LRRFIP2)

Leucine-rich repeat flightless-I-interacting protein 2 (LRRFIP2) is a multifunctional scaffold protein implicated in several signaling pathways, including Wnt signaling, Toll-like receptor (TLR) signaling, and inflammasome regulation[1][3][4][5]. LRRFIP2 interacts with Dishevelled (Dvl), acting as an activator of canonical Wnt/β-catenin signaling and promoting TCF/LEF-dependent transcription, thereby influencing embryonic development in vertebrates[1]. In the immune context, LRRFIP2 partners with the adaptor MyD88 to bind the cytosolic tail of Toll-like receptor 4 (TLR4), which leads to activation of nuclear factor kappa B (NF-κB) signaling and the induction of pro-inflammatory cytokines[3][4][5]. LRRFIP2 also dampens inflammasome activation by recruiting the caspase-1 inhibitor Flightless-I, thereby decreasing IL-1β maturation[3][4]. Alternative splicing generates multiple isoforms with potentially distinct regulatory capacities[1][5]. LRRFIP2 is considered a modulator rather than a core component of these pathways, adding regulatory complexity to vertebrate immune and developmental signaling. Note: - No approved or investigational drugs have been identified as directly targeting LRRFIP2 in current resources[3][4][5]. - The protein is not classified in common molecular families like receptor, ion channel, or enzyme, but rather functions as a scaffold/adaptor in key signaling pathways. - LRRFIP2 does not currently serve as a clinical biomarker or direct drug target, though it may have emerging roles in cancer biology and immunoregulation.

Other names

LRR binding FLII interacting protein 2LRR FLII-interacting protein 2HUFI-2Leucine-rich repeat (in FLII) interacting protein 2LRRFIP2