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Target intelligence / Profile preview
Leucine-rich repeat LGI family member 4 (LGI4)
- Target
- LGI4
- Molecular classification
- Other (Secreted protein; component of Schwann cell signaling pathway; not a classic receptor, enzyme, ion channel, or transporter)
01
Overview
Leucine-rich repeat LGI family member 4 (LGI4) is a secreted protein implicated in the regulation of myelination and axon segregation predominantly in the peripheral nervous system. It acts as a component of Schwann cell signaling pathways essential for proper nerve development. Mutations or dysfunction in LGI4 are associated with neurogenic disorders such as arthrogryposis multiplex congenita and childhood absence epilepsy. LGI4 is chiefly localized to the extracellular space and is expressed notably in nervous system tissues.
- Other names
- LGIL3UNQ6515/PRO21485LGI1-like protein 3leucine-rich glioma-inactivated protein 4AMC1AMCNMYleucine-rich glioma-inactivated gene 4
02
Biological functions
Regulation of myelinationControl of axon segregationNeurogenesisSchwann cell signaling
03
Disease associations
Arthrogryposis multiplex congenita, neurogenic typeChildhood absence epilepsyMyelin defects
04
Safety considerations
Disruption may lead to myelination defects and neurodevelopmental disease, suggesting possible adverse effects on nervous system integrity
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