Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1)

Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1) is a postsynaptic cell adhesion and synapse organizer protein, characterized by an extracellular leucine-rich repeat (LRR) domain and a single transmembrane domain[1][3][4][5]. LRRTM1 is preferentially expressed in the brain, where it is predominantly localized at excitatory synapses, especially in the hippocampus, visual thalamus, and other regions critical for synaptic connectivity[1][3][4][5]. It functions in the regulation of synapse density, the morphological integrity of excitatory synapses, synaptic plasticity (such as long-term potentiation), and cognitive processes including memory formation[1][3][4]. Loss-of-function studies in mice show that deletion of LRRTM1 impairs excitatory synapse development and reduces synaptic function in developing circuits, whereas in mature neurons, it contributes to the maintenance and functional properties of synaptic AMPA receptors[1]. LRRTM1 acts as a transsynaptic organizer, inducing presynaptic differentiation through binding to presynaptic neurexins, and is required for normal distribution of synaptic vesicle proteins such as VGLUT1[3][4]. Human genetic studies have associated LRRTM1 with handedness, schizophrenia, and reading disorders[5]. No approved drugs directly target LRRTM1, and it is not currently established as a direct drug target, biomarker, or safety concern in routine clinical practice[5].

Other names

LRRTM1Leucine rich repeat transmembrane neuronal 1LRRTM1 proteinUNQ675/PRO1309FLJ32082