Leucine-rich repeat transmembrane neuronal protein 2 (LRRTM2)

Leucine-rich repeat transmembrane neuronal protein 2 (LRRTM2) is a postsynaptic transmembrane protein enriched at excitatory synapses in the brain. It belongs to the LRRTM family of synaptic cell-adhesion molecules and contains leucine-rich repeat domains that mediate critical protein-protein interactions. LRRTM2 regulates the formation, maintenance, and nano-organization of excitatory synapses by interacting trans-synaptically with presynaptic Neurexins (Nrxns), specifically those lacking an insert at splice site 4. This binding organizes pre- and postsynaptic structures, aligns AMPA-type glutamate receptors (AMPARs) for efficient neurotransmission, and supports synaptic plasticity required for learning and memory. LRRTM2 dysfunction can disrupt synapse development and has been implicated in neurodevelopmental and psychiatric disorders, underscoring its importance for healthy brain connectivity and function. No clinically approved drugs directly target LRRTM2, but it remains a key molecule for basic and translational neuroscience research. If further information or specific details about expression, signaling pathways, or knockout phenotypes are required, these can be expanded using the cited sources.

Other names

LRRTM2KIAA0416LRRN2Leucine-rich repeat neuronal 2 proteinleucine-rich repeat transmembrane neuronal 2 protein

Not applicable for drugs, but LRRTM2 acts via trans-synaptic adhesion to Neurexins, promoting excitatory synapse formation and stabilizing AMPAR (AMPA receptor) localization at synapses