Leucine-rich single-pass membrane protein 2 (LSMEM2)

Leucine-rich single-pass membrane protein 2 (LSMEM2) is a leucine-rich, single-pass transmembrane protein (DUF4714 family) highly restricted to cardiomyocytes and skeletal muscle[2][1]. It localizes specifically to the intercalated discs of cardiomyocytes and to neuromuscular junctions in skeletal muscle[4]. The molecule is used as a cell-type-specific biomarker for authentic cardiomyocytes and is downregulated in failing heart tissue, suggesting its importance in normal cardiac function[1]. Its gene (C3orf45) encodes two isoforms, both biologically similar, with predicted post-translational modifications that may affect its role in cell junction organization, vesicle transport, and mitochondrial function[2][4]. Currently, its precise biological function is under investigation; however, evidence points to a role in intercellular coupling and energy metabolism, with pathology upon dysregulation in both cardiac and skeletal muscle[1][4]. There are no known direct drug interactions, but it is considered a cell surface biomarker and a potential research target for drug testing and cardiac disease modeling[1].

Other names

LSMEM2C3orf45FLJ38608leucine rich single-pass membrane protein 2