Leucine zipper protein 1 (LUZP1)

Leucine zipper protein 1 (LUZP1) is a cytoskeletal regulatory protein containing leucine zipper motifs and cross-linking domains that stabilize filamentous actin (F-actin) and regulate actin filament dynamics[4][3][2]. It localizes to the centrosome, actin cytoskeleton, and midbody, acting as a negative regulator of ciliogenesis and playing key roles in cell migration, division, and embryonic development[4][2][5][6]. Deletion or mutation of LUZP1 leads to cytoskeletal and ciliary abnormalities, with implications for congenital diseases (e.g., chromosome 1p36 deletion syndrome, Townes-Brocks syndrome) and potential contributions to cancer mechanisms by affecting cell invasion and migration[4][3][2]. LUZP1 interacts with other cytoskeletal proteins such as filamin A, ARP2, and ARP3, and contributes to the stabilization of chromatin remodeling complexes, but is not a validated target for pharmacological intervention[4][6][5].

Other names

LUZP1LUZPFimbacinFilamin mechanobinding actin cross-linking proteinfimbacin