Leucine zipper tumor suppressor 2 (LZTS2)

Leucine zipper tumor suppressor 2 (LZTS2) is a member of the leucine zipper tumor suppressor family, encoded by a gene located at chromosome 10q24.3—a locus frequently lost in diverse human tumors[1][2][4]. The LZTS2 protein contains a leucine zipper domain and a nuclear export signal, enabling interaction with and regulation of β-catenin, a critical mediator of Wnt signaling. LZTS2 negatively regulates β-catenin-mediated transcription, inhibits the Wnt signaling pathway, controls cell-cycle progression, and is required for cytokinesis through microtubule regulation[1][4]. Its tumor suppressor role is linked to repression of cell proliferation and prevention of tumorigenesis. Aberrant methylation and altered expression of LZTS2 have diagnostic and prognostic implications in cancer, especially liver and stomach cancers, where its expression can be modulated by epigenetic regulation[3][4]. Some compounds (including acetaminophen and environmental chemicals) are predicted to influence its expression, but no clinically established drugs target it directly.

Other names

Leucine zipper putative tumor suppressor 2KIAA1813LAPSER1hLZTS2Protein LAPSER1

Epigenetic modulation (e.g., methylation status) may affect gene expression[3]; Drugs potentially influence LZTS2 expression but direct mechanism of action in therapy not established[3]