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Target intelligence / Profile preview
Leucocyte Elastase (HLE)
- Target
- HLE
- Molecular classification
- Enzyme, Serine Protease, Proteinase S1 family
01
Overview
Leucocyte elastase, also known as neutrophil elastase, is a serine protease enzyme primarily found in the azurophilic granules of neutrophils. It plays a key role in immune defense by degrading proteins during inflammation and infection. Excessive activity or dysregulation leads to tissue damage implicated in several diseases, including chronic inflammatory diseases, acute conditions, and cardiovascular disease.
- Other names
- Neutrophil ElastaseHuman Leukocyte ElastaseELANEELA2Elastase 2Serine ElastaseGranulocyte Elastase
02
Mechanism of action
Inhibition of enzymatic activity
03
Biological functions
Pathogen destructionTissue remodelingFacilitates cell migrationImmune response
04
Disease associations
Pulmonary emphysemaRheumatoid arthritisPsoriasisMyocardial ischemia/infarctionPancreatitisCyclic neutropeniaEndotoxic shockChronic/acute lung diseaseCardiovascular diseaseThoracic aortic dissectionAtherosclerosis
05
Safety considerations
Potential for off-target effects of inhibitorsRisk of impaired immune function with excessive inhibition
06
Interacting drugs
Alpha-1 proteinase inhibitor (alpha-1 antitrypsin)
4 more in the full profile.
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