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Target intelligence / Profile preview
Leukemia Inhibitory Factor Receptor (LIFR)
- Target
- LIFR
- Molecular classification
- Receptor, Cytokine Receptor, Type I cytokine receptor
01
Overview
Leukemia Inhibitory Factor Receptor (LIFR), also known as CD118, is a cell surface receptor that mediates the actions of leukemia inhibitory factor (LIF) and other cytokines in the interleukin-6 family. Upon ligand binding and complex formation with gp130, several intracellular cascades are activated, including JAK/STAT, MAPK, and PI3K pathways. LIF/LIFR signaling has pleiotropic effects depending on tissue context, influencing cell proliferation, differentiation, survival, bone metabolism, neural development, embryogenesis, placental formation, maternal receptivity to blastocyst implantation, immunity, and tissue regeneration. A soluble form of the receptor exists which can inhibit biological activity by sequestering free ligand.
- Other names
- CD118
02
Mechanism of action
Agonist: LIF binding induces heterodimerization with gp130, activating JAK/STAT, MAPK, and PI3K signaling pathways. Antagonist: Soluble LIFR sequesters LIF, preventing it from binding to membrane-bound LIFR.
03
Biological functions
Cell proliferationCell differentiationCell survivalNeural developmentPlacental developmentImmune responseSignal transductionRegulation of gene expression
04
Disease associations
Developmental disordersInfertilityImmunopathological diseases
05
Safety considerations
Dysregulation can lead to developmental disordersPotential impact on fertility
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