Leukemia NUP98 fusion partner 1 pseudogene (LNP1 pseudogene)

The leukemia NUP98 fusion partner 1 pseudogene (LNP1 pseudogene, ENSG00000227785) is classified as a pseudogene in the human genome. Pseudogenes are non-functional segments of DNA that resemble functional genes but typically do not produce functional proteins. LNP1 pseudogene is not implicated as a therapeutic target, does not code for a functional protein, and is not directly associated with drug interactions or disease roles. There is limited functional or disease-relevance information for this locus, and several gene databases (GeneCards, Bgee) corroborate that it is described as a pseudogene, not as a protein-coding, receptor, enzyme, or disease-driver gene[1][2][4].\nKey clarifications:\n- This is a pseudogene—not a functional protein, enzyme, receptor, or known disease target[1][2][4].\n- There is no evidence to support that it serves as a therapeutic target for drug intervention or as a biomarker[1][2][4].\n- Its "leukemia" designation derives from its relationship to the *NUP98* gene, which is implicated in oncogenic fusions, but this specific pseudogene is not functionally involved in those processes[6][7]. \nSummary: ENSG00000227785/LNP1 pseudogene is not a true therapeutic target and contains no information supporting its utility in drug development, disease therapy, or biomarker roles[1][2][4]. Its assignment as a "target" is likely a misclassification or due to confusion with functional NUP98 fusion proteins, which are true oncogenic drivers, but are unrelated to this pseudogene locus.

Other names

AC092013.1LNP1 pseudogeneNP3LOC106865368[2][3]