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Leukocidin LukAB (LukAB)

Target: LukAB
Molecular classification: Pore-forming toxin, Bicomponent protein

Overview

Leukocidin LukAB (also known as LukGH) is a bicomponent pore-forming toxin produced by Staphylococcus aureus. It targets and lyses human phagocytes, particularly neutrophils, monocytes, macrophages, and dendritic cells, contributing to immune evasion. It binds to CD11b and forms an octameric beta-barrel pore, leading to cell death. As it is present in almost all S. aureus isolates it is a good target for vaccine development.

Other names: LukGHLeukocidin GH

Mechanism of action

Forms a transmembrane pore in host cells, leading to cell lysis.

Biological functions

Immune evasionCell lysisPore formationActivation of Caspase 1IL-1β secretionInflammasome activation

Disease associations

InfectionStaphylococcus aureus infectionMRSA infectionMSSA infection

Safety considerations

Potential for off-target effects if neutralizing antibodies are not highly specific.Species specificity makes animal models challenging for preclinical development.

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