Target intelligence / Profile preview

Leukocyte antigen CD37 (CD37)

Target: CD37
Molecular classification: Tetraspanin, Transmembrane 4 superfamily, Cell surface glycoprotein

Overview

Leukocyte antigen CD37 (CD37) is a cell surface glycoprotein belonging to the tetraspanin family. Highly expressed on mature B cells and malignant B cells in CLL, NHL and AML. It plays a crucial role in immune regulation, including B-cell and T-cell interactions, and acts as a tumor suppressor. CD37 is a therapeutic target for immunotherapies like monoclonal antibodies and CAR-T cells, and its expression level serves as a prognostic marker in certain lymphomas.

Mechanism of action

Targeting with monoclonal antibodies or CAR-T cells to induce cell death or immune-mediated clearance of CD37-expressing cells. Modulation of PI3K-Akt survival pathway.

Biological functions

Immune regulationSignal transductionCell developmentCell activationCell growthCell motilityCell adhesionCell migrationHumoral immune response controlCellular immune response controlT-cell–B-cell interaction

Disease associations

B-cell lymphomaNon-Hodgkin lymphoma (NHL)Chronic lymphocytic leukemia (CLL)Acute myeloid leukemia (AML)Diffuse large B-cell lymphoma (DLBCL)

Safety considerations

Potential for off-target effects on normal B cellsCytokine release syndrome (CRS) with CAR-T therapiesTumor lysis syndrome (TLS)

Interacting drugs

Monoclonal antibodies

3 more in the full profile.

Biomarkers

CD37 expression level (prognostic marker for DLBCL)CD37 status alongside other biomarkers for risk prediction

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