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Target intelligence / Profile preview
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1)
- Target
- LAIR1
- Molecular classification
- Immunoglobulin superfamily, Transmembrane glycoprotein, Receptor, Inhibitory receptor
01
Overview
LAIR1 is an inhibitory immune receptor expressed on most peripheral blood mononuclear cells. It binds to collagens and collagen-domain-containing proteins, leading to the recruitment of SHP phosphatases and inhibition of immune cell activation. It plays a role in maintaining immune tolerance and is implicated in autoimmune diseases, cancer, and infectious diseases.
- Other names
- CD305Leukocyte-associated immunoglobulin-like receptor 1
02
Mechanism of action
Upon ligand binding (collagens), ITIM motifs are phosphorylated, recruiting SHP family phosphatases (SHP-1/SHP-2) to inhibit cellular activation pathways.
03
Biological functions
Immune regulationInhibition of immune cell activationMaintenance of immune tolerance
04
Disease associations
Autoimmune diseasesCancerInfectious diseases
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