Target intelligence / Profile preview

Human Neutrophil Elastase (HNE)

Target: HNE
Molecular classification: Enzyme, Serine Protease

Overview

Human neutrophil elastase (HNE) is a serine protease enzyme found in neutrophils. It plays a crucial role in host defense by degrading proteins during inflammation and infection. However, its dysregulation is implicated in tissue damage and diseases like emphysema, cystic fibrosis, and congenital neutropenia. It is a target for drug discovery, with inhibitors like sivelestat under investigation for therapeutic use. Alpha-1 antitrypsin (A1AT) is the primary endogenous inhibitor.

Other names: Leukocyte elastaseELA2ELANEElastase 2Serine elastaseHuman leukocyte elastase (HLE)

Mechanism of action

Inhibition of neutrophil elastase activity.

Biological functions

Degradation of extracellular matrix proteinsBactericidal activityRegulation of inflammationModulation of immune cell functionsBlood coagulationTumor microenvironment remodeling

Disease associations

Emphysema/COPDCystic fibrosisCyclic/severe congenital neutropeniaInflammationAcute respiratory distress syndrome (ARDS)

Safety considerations

Potential for tissue damage due to broad substrate specificityDysregulation leading to inflammatory diseases

Interacting drugs

Sivelestat

1 more in the full profile.

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