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Leukocyte function-associated antigen 3 (LFA-3)

Target: LFA-3
Molecular classification: Cell surface glycoprotein

Overview

Leukocyte function-associated antigen 3 (LFA-3), also known as CD58, is a cell surface adhesion molecule that plays a critical role in immune cell interactions. It serves as a ligand for the T lymphocyte CD2 glycoprotein, facilitating essential contacts between T cells and other cells. This interaction is crucial for thymocyte development, immune synapse formation and effective immune responses. Altered expression of LFA-3 has been implicated in diseases such as Burkitt's lymphoma, where reduced levels may help tumor cells escape immunosurveillance.

Other names: CD58

Biological functions

Mediates intercellular adhesionThymocyte–epithelial interactionsT-cell–APC interactionsImmune synapse formationT cell activation

Disease associations

Tumor immunologyBurkitt's lymphoma

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