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Target intelligence / Profile preview
Leukocyte Immunoglobulin-Like Receptor B (LILRB)
- Target
- LILRB
- Molecular classification
- Receptor, Immunoglobulin-like receptor
01
Overview
The Leukocyte Immunoglobulin-Like Receptor B (LILRB) family comprises inhibitory immune receptors that regulate immune responses by transmitting inhibitory signals. They are characterized by extracellular immunoglobulin domains and intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs). LILRBs are expressed on various immune cells and bind to MHC class I molecules, including HLA-G, leading to the recruitment of phosphatases and downregulation of activating pathways. These receptors play a crucial role in maintaining self-tolerance, preventing autoimmunity, and are implicated in cancer immune evasion and infectious disease.
- Other names
- CD85ILT (Immunoglobulin-like Transcript)LIR (Leukocyte Immunoglobulin-Like Receptor)
02
Mechanism of action
Recruitment of phosphatases (SHP-1/SHP-2) to ITIM motifs, leading to dephosphorylation and inhibition of activating signaling pathways.
03
Biological functions
Immune regulationInhibition of immune cell activationMaintenance of self-toleranceRegulation of NK cell cytotoxicityRegulation of B cell differentiation and traffickingRegulation of phagocytosis
04
Disease associations
CancerAutoimmunityInfectious diseaseTransplant rejection
05
Safety considerations
Potential for immune suppressionOff-target effects on other immune cells
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