Leukocyte immunoglobulin-like receptor B2 (LILRB2)

Leukocyte immunoglobulin-like receptor B2 (LILRB2) is an immunosuppressive cell surface receptor that plays a key role in regulating immune responses and maintaining immune homeostasis. It functions as an inhibitory receptor that regulates both innate and adaptive immunity by suppressing activation signals in immune cells. LILRB2 binds to MHC-I molecules (including HLA-G) and angiopoietin-like proteins, leading to the recruitment of SHP-type phosphatases and inhibition of cell activation. It is being investigated as a therapeutic target in cancer and for neuroregeneration after CNS injury.

Other names

ILT4CD85dIg-like transcript 4

Recruitment of SHP-type phosphatases to inhibit downstream signaling pathways responsible for cell activation upon ligand engagement (MHC-I or angiopoietin-like proteins).