Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4)
- Target
- LILRA4
- Molecular classification
- Type I transmembrane protein, Receptor, Immunoglobulin-like receptor
01
Overview
Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4), also known as ILT7 and CD85g, is a type I transmembrane glycoprotein selectively expressed on human plasmacytoid dendritic cells (pDCs). It functions as an inhibitory coreceptor that modulates pDC function by forming a cell surface complex with FcεRIγ. Upon binding to its ligand, BST2/CD317/Tetherin, LILRA4/ILT7 inhibits Toll-like receptor-induced production of type I interferons and pro-inflammatory cytokines, contributing to the fine-tuning of innate immunity and potentially playing a role in tumor immune evasion.
- Other names
- ILT7CD85g
02
Mechanism of action
Inhibition of TLR-induced signaling in plasmacytoid dendritic cells via ITAM-mediated signaling upon ligand binding.
03
Biological functions
Immune response regulationInhibition of type I interferon productionModulation of plasmacytoid dendritic cell functionSignal transduction
04
Disease associations
Viral infectionTumor immune evasionAutoimmunity (potential)
05
Safety considerations
Potential for immune suppressionOff-target effects on other immune cells (if targeting LILRA4 therapeutically)Disruption of immune homeostasis
Beyond the preview
Go deeper on Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4).