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Target intelligence / Profile preview
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1)
- Target
- LILRB1
- Molecular classification
- Type I transmembrane glycoprotein, Receptor
01
Overview
LILRB1 is an inhibitory receptor expressed on a variety of immune cells, including B cells, monocytes/macrophages, NK cells, and T cells. It binds to MHC class I molecules and delivers inhibitory signals via ITIMs in its cytoplasmic tail, dampening immune cell activation. LILRB1 plays a role in maintaining self-tolerance and is implicated in tumor immune evasion, making it a target for immune checkpoint blockade strategies.
- Other names
- ILT2CD85jLIR-1
02
Mechanism of action
Immune checkpoint inhibition via blockade of LILRB1-mediated suppression of immune cell activation
03
Biological functions
Immune responseInhibitory receptor signalingRegulation of immune cell activationMaintenance of self-tolerance
04
Disease associations
CancerAutoimmunityInflammation
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