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Target intelligence / Profile preview
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4)
- Target
- LILRB4
- Molecular classification
- Receptor, Inhibitory immune receptor
01
Overview
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), also known as ILT3, LIR-5, or CD85k, is an inhibitory immune receptor with significant roles in immune regulation and disease pathology. It is primarily expressed on monocytic cells and upregulated in certain pathological conditions like AML and solid tumors. LILRB4 acts as an immune checkpoint molecule, negatively regulating activation signals by recruiting SHP phosphatases upon ligand engagement and ITIM phosphorylation. Targeting LILRB4 may enhance anti-tumor immunity, making it a promising candidate for cancer immunotherapy.
- Other names
- ILT3LIR-5CD85k
02
Mechanism of action
Recruitment of SHP phosphatases via phosphorylated ITIM motifs, leading to inhibition of protein tyrosine kinase-mediated activation signals.
03
Biological functions
Immune regulationInhibition of protein tyrosine kinase-mediated activation signalsSuppression of T cell proliferationInduction of T cell anergyPromotion of CD8+ suppressor T cell differentiationMaintenance of immune homeostasis
04
Disease associations
Acute Myeloid LeukemiaSolid TumorsAutoimmune DiseasesInfections
05
Biomarkers
Expression in AML with monocytic differentiation
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