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Leukocyte receptor cluster member 1 (LENG1)

Target: LENG1
Molecular classification: Protein coding gene, Located in the leukocyte receptor cluster (LRC) region, Encodes a nucleoplasmic protein (not a receptor on the cell surface)

Overview

Leukocyte receptor cluster member 1 (LENG1) is a protein-coding gene located in the leukocyte receptor complex on chromosome 19. It is predicted to localize to the nucleoplasm and contains domains suggesting a role in transcriptional regulation, possibly as a co-repressor. While named as part of the "leukocyte receptor cluster," there is no evidence it functions as a cell-surface receptor or direct participant in immune cell signaling or as a classical therapeutic target. LENG1 is not currently targeted by any drugs and has limited disease associations, connected through genetic studies rather than pharmacologic intervention.

Other names: LENG1

Biological functions

Likely involved in nuclear processes (based on nucleoplasmic localization)May play a role in transcriptional regulation (CBF1-interacting co-repressor CIR, N-terminal domain)

Disease associations

Associated with "Intellectual Developmental Disorder With Speech Delay, Autism, And Dysmorphic Facies" (likely as a gene variant, not as a drug target)Associated with "Sclerosteosis 1" (likely as a gene variant, not as a drug target)

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