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Leukocyte receptor cluster member 8 (LENG8)
- Target
- LENG8
- Molecular classification
- Scaffold/adaptor protein, Protein-containing complex (predicted), Other (not receptor, enzyme, transporter, ion channel, or transcription factor)
01
Overview
Leukocyte receptor cluster member 8 (LENG8) is a protein-coding gene broadly expressed across many human tissues. The protein is predicted to localize in the nucleus and participate as a scaffold or adaptor in protein-containing complexes. LENG8 is associated genetically with rare diseases such as combined oxidative phosphorylation deficiency 8 and common variable immunodeficiency 1, but it is not currently recognized as a major drug target or as having a defined role in pathways of widespread biomedical interest such as cancer, inflammation, or neurodegeneration. Its function appears related to nuclear processes and protein complex architecture, with few direct links to cell signaling, transcriptional regulation, or therapeutic modulation
- Other names
- LENG8KIAA1932MGC40108pp13842leukocyte receptor cluster member 8leukocyte receptor cluster (LRC) member 8
02
Mechanism of action
no drugs targeting, so no mechanisms documented
03
Biological functions
Predicted scaffold/adaptor activityFormation of protein-containing complexes (predicted)Nuclear localization (predicted)
04
Disease associations
Combined oxidative phosphorylation deficiency 8Immunodeficiency, common variable, 1 (gene-disease association via genetic studies)Other (no major cancer or inflammation roles identified)
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