Leukocyte receptor cluster member 9 (LENG9)

Leukocyte receptor cluster member 9 (LENG9) is a human protein-coding gene located on chromosome 19q13.42 that encodes a 501-amino acid protein with predicted zinc finger and RNA-binding domains, but with largely uncharacterized function[1][3][5]. LENG9 is expressed most strongly in skeletal muscle and fetal liver, and is also found in immune-related and reproductive tissues such as the cervix, lung, and placenta[1][2]. Functional genomics suggest it may participate in regulation of the innate immune response, particularly in macrophages, and modulate cell cycle progression via interactions with proteins such as CDC5L[1][2]. LENG9 is post-translationally modified (phosphorylation, acetylation, sumoylation, GPI anchoring) and predicted to localize to the mitochondria or cytoplasm, depending on the species[1]. Recent transcriptomic studies implicate LENG9 in both reproductive disorders (through miRNA regulation in endometrial cells) and as a cancer biomarker or putative driver gene (in cervical and prostate tumors), although its precise molecular mechanism and therapeutic relevance remain undefined[2]. There are currently no known drugs targeting LENG9 directly, and no mechanistic information for pharmaceutical modulation is available.

Other names

LENG9Leukocyte receptor cluster (LRC) member 9LENG9_HUMANLENG9 gene