Leukocyte removal

Leukocyte removal (leukoreduction) is a blood processing technique used to eliminate white blood cells from blood products through physical filtration mechanisms such as barrier retention, adhesion to filter fibers, and manipulation of filter pore size and surface charge[2][3][4]. The purpose is to reduce transfusion-related risks including infectious disease transmission, immunological reactions like alloimmunization, and non-hemolytic transfusion reactions[5][6]. Leukoreduction is not a molecular or receptor target; rather, it describes a clinical procedure in transfusion medicine. Filters are engineered to maximize leukocyte capture by optimizing mechanical entrapment and chemical adhesion, while minimizing loss of desired blood cells and maintaining product viability[2][3][4].

Other names

LeukoreductionLeukocyte reductionLeukodepletionLeukocyte extraction