Target intelligence / Profile preview

Leukotriene A-4 Hydrolase

Molecular classification: Enzyme, Metalloprotein, Hydrolase, Aminopeptidase

Overview

Leukotriene A-4 hydrolase (LTA4H) is a bifunctional zinc metalloenzyme that catalyzes the conversion of leukotriene A4 (LTA4) to leukotriene B4 (LTB4), a potent pro-inflammatory mediator. It also exhibits aminopeptidase activity, cleaving N-terminal arginines from peptides. It plays a critical role in inflammatory signaling pathways and is implicated in various inflammatory diseases, making it a therapeutic target for controlling excessive inflammation. Inhibitors of LTA4H offer potential benefits for treating inflammatory conditions.

Other names: LTA4HLTA_hydrolaseLTA_HLeukotriene A4 hydrolase

Mechanism of action

Inhibition of LTA4H, blocking the conversion of LTA4 to LTB4.

Biological functions

Arachidonic acid metabolismLeukotriene biosynthesisInflammationPeptide hydrolysis

Disease associations

InflammationArthritisDermatitisCOPDNephritisAllergic reactions

Safety considerations

Potential for broad immune suppression with non-selective inhibitors.Off-target effects due to aminopeptidase activity.

Interacting drugs

AKST1220

1 more in the full profile.

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