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Target intelligence / Profile preview
Leukotriene B4 receptor 2 (BLT2)
- Target
- BLT2
- Molecular classification
- G protein-coupled receptor (GPCR)
01
Overview
Leukotriene B4 receptor 2 (BLT2) is a G protein-coupled receptor that binds leukotriene B4 (LTB4) with lower affinity than BLT1, but also binds other eicosanoids like 12-HHT with higher affinity. It is ubiquitously expressed and mediates chemotaxis/migration regulation for granulocytes/macrophages and modulates inflammation. It is a potential therapeutic target for anti-inflammatory drug development and potentially modulating cancer progression pathways.
- Other names
- BLTR2LTB4R2
02
Mechanism of action
Antagonism of BLT2 receptor to inhibit chemotaxis and inflammation
03
Biological functions
ChemotaxisMigration regulation for granulocytes/macrophagesModulates inflammationG-protein signalingPhosphatidylinositol-calcium second messenger system
04
Disease associations
InflammationAllergyCancer
05
Safety considerations
Potential for off-target effects due to broad tissue distributionComplex and sometimes opposing roles in inflammation compared to BLT1
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