Leukotriene B4 receptor type 2 (BLT2)

Leukotriene B4 receptor type 2 (BLT2) is a **low-affinity G protein-coupled receptor** for leukotriene B4 (LTB4) and is encoded by the LTB4R2 gene. Unlike the high-affinity BLT1 receptor, BLT2 is expressed more broadly across tissues, including skin, intestine, liver, and spleen, and is upregulated in inflammatory or stress conditions. Its main endogenous ligands are 12-HHT and LTB4, though it can also bind related lipids. BLT2 activation promotes cell migration, chemotaxis, wound healing, and contributes to epithelial barrier function; it also drives production of reactive oxygen species and in some contexts, can facilitate cell proliferation and inflammatory cytokine production. It plays roles in diseases linked to **inflammation, cancer, asthma, atherosclerosis, and wound repair**. The BLT2/12-HHT axis has been shown to accelerate skin wound healing by driving keratinocyte migration and production of TNF and MMPs, without heightening inflammation. Overexpression or dysregulation of BLT2 can promote disease progression, making it a possible **therapeutic target** for both pro- and anti-inflammatory interventions as well as wound repair

Other names

Leukotriene B4 receptor 2LTB4R2Low-affinity leukotriene B4 receptorBLTR2

Activation of Gi- and Gq-type G proteins, leading to decreased cAMP and increased intracellular calcium; Chemotaxis and migration of epithelial/immune cells; Increased ROS production; Induction of TNF and matrix metalloproteinases (in wound healing context)