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Leukotriene Pathway

Molecular classification: Metabolic Pathway, Lipid signaling pathway

Overview

The leukotriene pathway refers to a series of biochemical reactions that produce leukotrienes, which are potent lipid mediators derived from arachidonic acid. These molecules play critical roles in inflammation, immune cell recruitment, and smooth muscle contraction, particularly in the context of allergic and inflammatory diseases.

Other names: Arachidonic acid lipoxygenase pathwayLeukotriene biosynthesis pathway

Mechanism of action

Leukotriene receptor antagonism; 5-lipoxygenase inhibition

Biological functions

InflammationImmune cell recruitmentSmooth muscle contractionEicosanoid signalingLipid metabolism

Disease associations

AsthmaAllergic rhinitisAtopic dermatitisAnaphylaxisNeuroinflammatory disordersParkinson's disease

Interacting drugs

Montelukast

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