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Target intelligence / Profile preview
Levodopa (L-DOPA)
- Target
- L-DOPA
- Molecular classification
- Amino acid, Phenethylamine, Catecholamine, Prodrug
01
Overview
Levodopa (L-DOPA) is a naturally occurring amino acid and the metabolic precursor to dopamine. It crosses the blood-brain barrier and is converted into dopamine in the brain, increasing dopamine levels. It is primarily used to treat Parkinson’s disease to alleviate motor symptoms. It is usually administered with a dopa decarboxylase inhibitor such as carbidopa or benserazide.
- Other names
- L-3,4-dihydroxyphenylalanine
02
Mechanism of action
Converted to dopamine in the brain, acting as a non-selective agonist at dopamine receptors (D1, D2, D3, D4).
03
Biological functions
Dopamine precursorNorepinephrine precursorEpinephrine precursor
04
Disease associations
Parkinson's diseaseParkinsonismRestless legs syndromeDopamine-responsive dystonia
05
Safety considerations
NauseaVomitingDyskinesiasWearing-off phenomenonPsychiatric disturbancesImpulse control disordersOxidative stressPotential changes in serotonergic transmissionRisk of neurotoxicity
06
Interacting drugs
Carbidopa
1 more in the full profile.
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