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Target intelligence / Profile preview
Lewis-A-like Glycotope (AbGn-7 antigen)
- Target
- AbGn-7 antigen
- Molecular classification
- Carbohydrate, Glycan, Glycol-epitope
01
Overview
The Lewis-A-like glycotope (AbGn‑7 antigen) is a carbohydrate epitope structurally similar to the Lewis A blood group antigen, highly expressed on tumor cells of various gastrointestinal cancers. It is targeted by monoclonal antibodies and antibody-drug conjugates for cancer therapy due to its restricted expression profile and ability to induce apoptosis, CDC, and ADCC in tumor cells.
- Other names
- AbGn-7AG‑7Lewis A-like antigenAbGn-7/Lewis A-like epitope
02
Mechanism of action
Antibody binding to Lewis-A-like glycotope, inducing apoptosis (caspase-independent), complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC); delivery of cytotoxic payload via ADC (AbGn-107).
03
Biological functions
Cell surface antigenTumor cell recognition
04
Disease associations
CancerColorectal cancerGastric cancerPancreatic cancerBiliary tract cancersGastrointestinal malignancies
05
Safety considerations
InfectionsCytopeniasHyponatremiaFatigueAbdominal painDiarrheaOff-target binding (limited, but possible)
06
Interacting drugs
AbGn-7
2 more in the full profile.
07
Biomarkers
AbGn-7 antigen expression level in tumor tissue
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