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Target intelligence / Profile preview
Lewis Y Antigen (LeY)
- Target
- LeY
- Molecular classification
- Carbohydrate, Glycan, Oncofetal antigen, Histo-blood group antigen
01
Overview
The Lewis Y antigen (LeY) is a fucosylated tetrasaccharide carbohydrate molecule overexpressed on the surface of various solid tumors, including those of the lung, intestine, breast, prostate, pancreas, esophagus, stomach, colon, rectum, and ovary. It functions in cell adhesion, promoting tumor invasion and metastasis. Due to its restricted expression profile outside of tumors, LeY is considered a promising target for chimeric antigen receptor (CAR) T-cell therapies and other immunotherapeutic strategies.
- Other names
- MH9Z13QV44UNII-MH9Z13QV44
02
Mechanism of action
Target for CAR T-cell therapy to induce tumor cell lysis.
03
Biological functions
Cell adhesionTumor invasionMetastasis
04
Disease associations
CancerOvarian cancerLung cancerColon cancerBreast cancerProstate cancerPancreatic cancerEsophageal cancerStomach cancerRectal cancer
05
Safety considerations
Potential for off-target effects due to expression in some normal tissuesCytokine release syndrome (CRS) with CAR T-cell therapyNeurotoxicity with CAR T-cell therapy
06
Biomarkers
Overexpression in tumor tissueElevated levels in serum (potential)
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