Target intelligence / Profile preview

Lewis Y Carbohydrate Antigen (None)

Target: None
Molecular classification: Carbohydrate antigen, Glycoconjugate, Oligosaccharide

Overview

Lewis Y is a difucosylated oligosaccharide carbohydrate antigen expressed on glycoconjugates. It is overexpressed in many epithelial cancers and mediates cell adhesion, contributing to tumor invasion and metastasis. It serves as a target for antibody-based therapies and CAR-T cell approaches.

Other names: Lewis Y antigenLeYCD174

Mechanism of action

Targeted by antibody-based therapies and CAR-T cell therapies

Biological functions

Cell adhesionTumor invasionMetastasisEmbryogenesisCell proliferation

Disease associations

Cancer

Safety considerations

Potential cross-reactivity with related structures on normal blood cellsOn-target, off-tumor toxicity

Biomarkers

Overexpression in tumor tissueSoluble Lewis Y levels in serum

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