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Target intelligence / Profile preview
LHFPL tetraspan subfamily member 7 (LHFPL7)
- Target
- LHFPL7
- Molecular classification
- Tetraspan transmembrane protein, Other
01
Overview
LHFPL tetraspan subfamily member 7 (LHFPL7), also known as TMEM211, is a protein-coding gene in humans located at chromosome 22q11.23 and encodes a 200-amino acid protein predicted to have four transmembrane regions[2][3][4]. It is a member of the lipoma HMGIC fusion partner-like (LHFP) gene family, a tetraspan transmembrane protein superfamily[3]. While its precise biological function remains unclear, recent evidence suggests that high expression of LHFPL7 (TMEM211) correlates with increased metastatic potential and poor prognosis in colon cancer, possibly through activation of the ERK, AKT, and NF-κB pathways and regulation of epithelial–mesenchymal transition markers[2]. It is not currently established as a common or validated therapeutic target, and there are no known drugs directly acting on LHFPL7. Its clinical and functional relevance requires further research.
- Other names
- TMEM211bA9F11.1Transmembrane protein 211LHFPL tetraspan subfamily member 7 protein
02
Biological functions
Membrane localizationPutative involvement in cell signaling (based on tetraspan superfamily)Possible regulation of epithelial-mesenchymal transitionPossible involvement in ERK, AKT, and NF-κB signaling pathways[2][3][5]
03
Disease associations
Inflammatory bowel disease (association)Possible role in cancer metastasis (colon cancer)[2][3]
04
Biomarkers
High expression associated with poor prognosis in colon cancer (correlation with EMT markers such as Snail, Twist1, Slug, and N-cadherin)[2]
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