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Target intelligence / Profile preview
Ligand-dependent nuclear receptor corepressor-like protein (LCORL)
- Target
- LCORL
- Molecular classification
- Transcription factor, DNA-binding protein
01
Overview
LCORL (Ligand-dependent nuclear receptor corepressor-like protein) is a DNA-binding transcription factor with critical roles in sperm development and regulation of skeletal growth and body size. Genetic variations in LCORL are robustly associated with height and skeletal morphology in humans, as well as rapid growth and body conformation in several animal species. LCORL may act in different isoforms—as a transcription factor and potentially as an accessory protein for polycomb repressive complex 2 (PRC2), which is involved in epigenetic silencing and developmental gene regulation. Despite significant research implicating LCORL in developmental biology and animal breeding, there is currently no evidence for direct pharmacological targeting, nor known small molecule or biologic drugs that interact with LCORL.
- Other names
- LCORLMLR1FLJ30696LCOR-like proteinMBLK1-related proteintranscription factor MLR1ligand dependent nuclear receptor corepressor like protein
02
Biological functions
Regulation of gene transcriptionRegulation of skeletal growth and body sizeSpermatogenesis
03
Disease associations
Growth disordersSkeletal/morphological traits modulation (e.g., stature, trunk/hip axis length)Potential roles in reproductive disorders linked to sperm functionAnimal breeding and livestock growth traits (QTL associations in cattle, horses, pigs, dogs, goats, sheep)
04
Biomarkers
Genetic variants/polymorphisms (for stature prediction, animal breeding selection, developmental biology studies)
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