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Target intelligence / Profile preview
LIM Domain Kinase 1 (LIMK1)
- Target
- LIMK1
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
LIMK1 is a serine/threonine protein kinase that regulates actin cytoskeleton dynamics by phosphorylating and inactivating cofilin proteins. It plays a critical role in cell motility, cell cycle progression, neuronal development, and has been implicated in diseases such as Williams Syndrome and cancer, making it a potential therapeutic target.
02
Mechanism of action
Inhibition of LIMK1 kinase activity, leading to altered actin dynamics.
03
Biological functions
Regulation of actin cytoskeleton dynamicsCell motilityCell cycle progressionNeuronal developmentSynapse maturation
04
Disease associations
Williams SyndromeCancerNeurological Disorders
05
Safety considerations
Potential for off-target effects due to kinase family similarityUnknown long-term effects of actin cytoskeleton modulation
06
Interacting drugs
TH251
07
Biomarkers
LIMK1 expression levels in tumor tissue
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