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LIM domain kinase 2 (LIMK2)

Target: LIMK2
Molecular classification: Serine/threonine-protein kinase

Overview

LIM domain kinase 2 (LIMK2) is a serine/threonine-protein kinase that regulates actin filament dynamics by phosphorylating cofilin, thereby inhibiting its actin-depolymerizing activity and stabilizing filamentous (F)-actin. It plays essential roles in cell morphology changes, embryonic development, and has been implicated as an oncogene in certain cancers. LIMK2 is activated by phosphorylation through Rho-associated kinase (ROCK), linking extracellular signals to changes in the cytoskeleton.

Mechanism of action

Phosphorylation of cofilin, inhibiting its actin-depolymerizing activity

Biological functions

Actin cytoskeleton regulationSpindle dynamicsCell morphology

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CancerCognitive disabilities

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LIMKi3

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