LIM domain only protein 1 (LMO1)

LIM domain only protein 1 (LMO1) is a nuclear transcriptional co-regulator characterized by two cysteine-rich LIM domains but lacking a DNA-binding domain[1][2][3]. LMO1 acts as a key scaffold/adaptor in multi-protein transcription complexes, influencing gene expression by interacting with other transcription factors, and is a known proto-oncogene. While LMO1 fulfills roles in cell fate determination, proliferation, and tissue development, it is best known for its critical role in driving tumor initiation and progression in several cancers, particularly neuroblastoma and T-cell acute lymphoblastic leukemia, in which its aberrant expression—often due to genetic alterations or enhancer polymorphisms—leads to increased malignancy, cellular proliferation, invasion, and metastasis[1][2][3][6]. LMO1 is also implicated in regulating signaling networks such as NF-κB in glioma and operates as part of core regulatory circuitry in specific cancer types[6][1]. No approved drugs currently target LMO1 directly.

Other names

Rhombotin-1RBTN1RHOM1TTG1Cysteine-rich protein TTG-1LIM domain only 1 (rhombotin 1)T-cell translocation gene 1T-cell translocation protein 1