Limb development membrane protein 1 like (LMBR1L)

Limb development membrane protein 1 like (LMBR1L) is a multi-transmembrane domain receptor, predominantly localized to the endoplasmic reticulum and plasma membrane. It is essential for proper lymphocyte development and immune function. LMBR1L forms a complex with the E3 ubiquitin ligase GP78 (AMFR) and UBAC2, facilitating the ubiquitin-mediated degradation of β-catenin and Wnt co-receptors (FZD6 and LRP6), thus acting as a negative regulator of the canonical Wnt/β-catenin signaling pathway in immune cells. Beyond its immunological role, LMBR1L also functions as a receptor mediating endocytosis for extracellular lipocalins, such as LCN1 (lipocalin-1). Loss-of-function mutations in this protein result in severe immunodeficiency in animal models due to blockages in lymphoid lineage development and increased cell death, emphasizing its crucial homeostatic role in the immune system.

Other names

LMBR1LKIAA1174LIMRUNQ458/PRO783FLJ10494limb region 1 protein homolog-likelipocalin-1-interacting membrane receptorlimb region 1-like proteinlimb region 1 homolog-likelipocalin-interacting membrane receptorLMBR1L protein1110013E13RikD15Ertd735elimb development membrane protein 1-likeRG130963

Drugs (hypothetical) targeting LMBR1L could modulate Wnt/β-catenin pathway by enhancing or inhibiting degradation of β-catenin and Wnt receptors (if developed)