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Target intelligence / Profile preview
Limbal Epithelial Stem Cell
- Molecular classification
- Stem cell
01
Overview
Limbal epithelial stem cells are critical adult unipotent progenitors responsible for lifelong renewal and repair of human corneal epithelium. Their deficiency leads directly to severe ocular surface disease with significant morbidity. Advances in bioengineering have enabled successful clinical therapies based on isolation/expansion/transplantation approaches targeting this unique cell population for sight restoration in affected patients.
- Other names
- LSCLimbal stem cellCorneal epithelial stem cell
02
Biological functions
Renewal of corneal epitheliumRegeneration of corneal epitheliumMaintenance of ocular surfacePrevention of conjunctival epithelial cell migration
03
Disease associations
Limbal Stem Cell Deficiency (LSCD)Corneal neovascularizationCorneal scarringVision loss
04
Safety considerations
Graft rejection (allogeneic transplantation)Risk of infectionLimited availability of autologous tissuePotential for incomplete corneal regeneration
05
Biomarkers
p63α (ΔNp63α isoform)ABCG2 transporter proteinCytokeratin 15/19 (K15/K19)Integrin α9β1
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