Target intelligence / Profile preview

Limosilactobacillus reuteri (L. reuteri)

Target
L. reuteri
Molecular classification
Other (classified as a probiotic lactic acid bacterium, not a receptor, enzyme, channel, transporter, or typical therapeutic protein)
01

Overview

Limosilactobacillus reuteri is a probiotic lactic acid bacterium found naturally in the gut and other body sites of humans and animals. It is notable for producing antimicrobial substances, especially reuterin, which inhibits the growth of pathogens without harming beneficial microbiota. L. reuteri strains exhibit anti-inflammatory and immunomodulatory effects, enhance gut barrier function, and can biosynthesize nutrients like folate and vitamin B12. It has been studied for roles in managing gastrointestinal infections, inflammatory and metabolic diseases, and as a general probiotic to support host health[1][3][4]. The term "Limosilactobacillus reuteri enhancement" refers to increasing the presence or activity of this probiotic, not to a molecular drug target.

Other names
formerly known as Lactobacillus reuterialso referred to as L. reuteri
02

Mechanism of action

Secretions of antimicrobial agents (e.g., reuterin inhibits growth of various pathogens by targets such as ribonucleotide reductase in microbes). Modulation of immune response (increase in anti-inflammatory cytokines, decrease in pro-inflammatory cytokines such as TNF-α). Competition with pathogens for gut colonization or adherence.

03

Biological functions

Modulation of gut microbiotaProduction of antimicrobial compounds (e.g., reuterin, reutericyclin)Immunomodulation (anti-inflammatory cytokine modulation, e.g., lowering TNF-α)Enhancement of gut barrier functionNutrient biosynthesis (folate, cobalamin/vitamin B12)
04

Disease associations

Infections (inhibition of pathogens such as Escherichia coli, Salmonella typhimurium, Helicobacter pylori)Gastrointestinal disorders (gut health, possible irritable bowel syndrome)Metabolic and inflammatory diseases (obesity, hepatic disorders, insulin sensitivity)Potential anti-aging effects (in model organisms)
05

Safety considerations

Generally recognized as safe for most human applications as a probioticNo intrinsic virulence, and strains such as DSM 17938 lack antibiotic resistance genesImmunocompromised patients may require caution, as with any live microbe supplementation
06

Interacting drugs

None (not a traditional drug target; however, L. reuteri is sometimes used as an *adjuvant* alongside drugs such as omeprazole for H. pylori therapy)
07

Biomarkers

Abundance of L. reuteri in gut microbiota (measured by metagenomic or microbiome analysis)Levels of reuterin in biological samples (occasionally measured in research settings)

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