Lin-9 DREAM MuvB core complex component (LIN9)

Lin-9 DREAM MuvB core complex component (LIN9) is a tumor suppressor protein and critical regulator of the cell cycle, acting as a core member of the MuvB multiprotein complex. In quiescent cells, LIN9 partners with p130, E2F4/DP1 to form the DREAM complex, which represses expression of E2F target genes and other cell cycle genes. When the cell re-enters the cycle, the MuvB core (including LIN9) dissociates from the repressive module and instead recruits transcription factors such as B-Myb and FoxM1, enabling activation of G2/M genes essential for mitosis. LIN9 thus serves as a molecular switch, coordinating repression of proliferation genes in non-dividing cells and their activation during proliferation. Dysfunction or altered regulation of LIN9/MuvB is implicated in tumorigenesis, as well as in HPV-mediated cell cycle dysregulation via viral oncoprotein interaction. LIN9 is a scaffold protein for other MuvB subunits, assembling with RBAP48, LIN52, LIN37, and LIN54 to mediate these critical transcriptional roles[1][2][3][4][6][8].

Other names

Protein lin-9 homologBARATGSHuLin-9hLin-9BARPsvTGS1TGS2Beta subunit-associated regulator of apoptosisTUDOR gene similar proteinType I interferon receptor beta chain-associated proteinpRB-associated proteinRb related pathway actorPRB-associated proteinLIN-9[1][3][5]

Experimental: Disruption of MuvB protein-protein interfaces to alter cell cycle gene expression, particularly in cancers with B-Myb overexpression (preclinical target concepts)[6]