LIN28A pseudogene 3 (LIN28AP3)

LIN28A pseudogene 3 (LIN28AP3) is a DNA sequence similar to the protein-coding LIN28A gene but classified as a pseudogene, indicating that it does not encode a functional protein. Pseudogenes arise from gene duplication or retrotransposition events and tend to lack biological activity other than potential regulatory effects in exceptional cases. LIN28AP3 is not considered a therapeutic target, and there is no evidence that it plays any known role in biology, pathology, or clinical pharmacology. The functional LIN28A protein (not LIN28AP3) is a highly conserved RNA-binding protein involved in pluripotency, cell growth, and cancer, but LIN28AP3 does not share these features[1][2][3][4][5].\n\nKey caveat: If the intention was to reference the genuine LIN28A protein (gene symbol: LIN28A), which is well-studied and potentially targetable for therapy, then this is a misidentification—the pseudogene LIN28AP3 itself is not an actionable target.

Other names

LIN28AP3