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Target intelligence / Profile preview
LINE1 Reverse Transcriptase (L1-RT)
- Target
- L1-RT
- Molecular classification
- Enzyme, Reverse Transcriptase
01
Overview
LINE1 reverse transcriptase is an enzyme encoded by the ORF2 region of LINE-1 retrotransposons. It catalyzes the synthesis of complementary DNA from its own RNA template during retrotransposition. It has implications for genomic diversity, evolution, and disease, particularly cancer. Pharmacologic inhibition or RNA interference targeting LINE‑1 RT has shown potential anti-cancer effects.
- Other names
- Long Interspersed Nuclear Element-1 Reverse TranscriptaseORF2p Reverse Transcriptase
02
Mechanism of action
Inhibition of reverse transcription
03
Biological functions
cDNA synthesisRetrotranspositionGenome maintenanceProcessed pseudogene formation
04
Disease associations
CancerGenetic diseasesAgingAutoimmune diseases
05
Safety considerations
Potential for off-target effectsInsertional mutagenesis
06
Interacting drugs
Efavirenz
2 more in the full profile.
07
Biomarkers
Autoantibodies against LINE-1 proteins
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