Target intelligence / Profile preview

Lingual nerve

Molecular classification
Other
01

Overview

The lingual nerve is a large branch of the mandibular division of the trigeminal nerve (cranial nerve V3), responsible for providing general sensory innervation—including touch, pain, and temperature—to the mucosa of the anterior two-thirds of the tongue, the floor of the mouth, and the lingual gingiva. It is joined by the chorda tympani branch of the facial nerve (cranial nerve VII), which provides taste sensation and parasympathetic fibers to the anterior two-thirds of the tongue as well as the submandibular and sublingual glands. The lingual nerve is purely a peripheral nerve and not a therapeutic molecular target. It is frequently at risk of injury during oral and dental procedures[1][2][4][5].

Other names
Nervus lingualis (Latin)Lingual branch of mandibular nerve
02

Mechanism of action

Local anesthetic blockade of nerve conduction (when clinically relevant)

03

Biological functions

Sensory innervationTaste sensationParasympathetic (secretomotor) innervation
04

Disease associations

Nerve injury (oral surgery, dental procedures)Neuropathic painAltered taste sensationNumbness (Other)
05

Safety considerations

Risk of nerve injury during dental or oral surgery, resulting in pain, paresthesia, dysgeusia (taste disturbance), or numbness
06

Interacting drugs

Local anesthetics (e.g., lidocaine used in dental procedures)

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