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Linoleic acid metabolism pathway
- Molecular classification
- Other
01
Overview
The **linoleic acid metabolism pathway** refers to the series of biochemical processes by which linoleic acid, an essential omega-6 polyunsaturated fatty acid, is enzymatically converted into longer chain and more highly unsaturated fatty acids such as gamma-linolenic acid (GLA), dihomo-gamma-linolenic acid (DGLA), and arachidonic acid (AA), as well as various biologically active lipid mediators, including prostaglandins, leukotrienes, and endocannabinoids. These metabolites are critical in regulating inflammation, immune response, and cellular signaling. Dysregulation of this pathway is implicated in diseases such as cardiovascular disease, metabolic syndrome, cancer, and inflammatory disorders. Enzymes involved include delta-6 desaturase, elongases, cyclooxygenases, lipoxygenases, and cytochrome P450s[1][2][3][5][7].
- Other names
- LA metabolismomega-6 fatty acid metabolismPUFA metabolism
02
Biological functions
Cell signalingInflammation modulationLipid metabolismPrecursor to arachidonic acid and other lipid mediatorsMaintenance of cellular membrane structure and function
03
Disease associations
Cardiovascular diseaseInflammationMetabolic syndromeCancerImmune response/infection
04
Biomarkers
Arachidonic acidProstaglandinsLeukotrienesHydroxyoctadecadienoic acids (9-HODE, 13-HODE)Oxidized linoleic acid metabolites
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